Is Rejuran HB Plus Less Painful Than Rejuran Healer? Ingredients That Make the Difference in Pain and Results
Is Rejuran HB Plus Less Painful Than Rejuran Healer? Ingredients That Make the Difference in Pain and Results
| From Signs of Dry, Rough Skin to the Differences Between Rejuran HB Plus and Rejuran Healer and Post-Treatment Precautions
Skin that feels moisturized immediately after cleansing can become tight again within just a few hours, and fine lines or flaking may look more noticeable once makeup is applied. Dry, rough-looking skin does not simply mean a lack of glow. It can also include rapid moisture loss, a rough skin surface, reduced firmness, and makeup that does not sit smoothly. Heating and air conditioning, dry seasons, frequent cleansing, and UV exposure can make these changes more noticeable.
When skin feels increasingly dry and rough, it is natural to wonder how to address texture and fine lines in addition to hydration. Both Rejuran HB Plus and Rejuran Healer are based on PN, but they differ in their additional ingredients and in how treatment-related discomfort is addressed. Below, we compare the composition and purpose of the two products, four skin booster options, pain-related differences, precautions, and frequently asked questions.

Rejuran HB Plus Key Takeaways
- Dry, Rough Skin may appear as tightness, rough texture, makeup lifting, and fine lines
- Shared PN Base is used in both products and is intended to support concerns such as skin texture and fine lines
- HB Plus Formulation combines PN with Hyaluronic Acid and Lidocaine to address hydration and injection-related discomfort
- Healer Formulation is centered on PN and does not include a separate local anesthetic ingredient
- Perceived Discomfort can vary not only by formulation but also by skin thickness, injection site, and anesthesia method
1. What Is Rejuran HB Plus?
The term HB Plus refers to the product’s ingredient composition. Rejuran HB Plus contains PN (Polynucleotide), Hyaluronic Acid (HA), and Lidocaine, a local anesthetic. PN is a core ingredient used to support skin texture and fine lines, while Hyaluronic Acid is known for attracting and retaining moisture. Lidocaine is included to help reduce discomfort during injection.
Rejuran Healer is also based on PN, but its formulation differs from HB Plus, which includes Hyaluronic Acid and Lidocaine. Rather than recommending one product universally, factors such as the degree of dryness, location of fine lines, sensitivity to injection discomfort, and allergy history should be considered. The treatment area and injection technique should be selected according to the characteristics of the product and the individual skin condition.
Three Key Ingredients in Rejuran HB Plus
① PN — Skin Texture Care — A core ingredient in the Rejuran line used to support overall skin condition and fine lines.
② HA — Moisture Retention — Uses the moisture-binding properties of Hyaluronic Acid to address dryness and surface skin condition.
③ Lidocaine — Pain Reduction — A local anesthetic included to reduce injection-related discomfort, although it does not eliminate pain completely.
2. Rejuran HB Plus vs. Rejuran Healer: Differences in Benefits and Features
Both products belong to the same PN-based category, but their additional ingredients serve different roles. Rather than ranking one above the other, it is more useful to compare them based on skin concerns and what matters most during the injection process.
| Item | Rejuran HB Plus | Rejuran Healer |
|---|---|---|
| Ingredient Composition | A combination formulation containing PN, Hyaluronic Acid (HA), and Lidocaine. | A PN-centered formulation without added Hyaluronic Acid or Lidocaine. |
| Treatment Focus | Supports skin texture and fine lines while also considering dryness and hydration. | Focuses on PN-based care for skin texture, fine lines, and overall skin condition. |
| Pain-Related Features | Contains a local anesthetic ingredient designed to reduce discomfort during injection. | Does not contain an anesthetic ingredient, so separate methods such as numbing cream may be considered if needed. |
| Selection Considerations | May be considered when hydration and injection-related discomfort are primary concerns. | When considering a PN-focused formulation, skin condition and treatment goals should be assessed. |
※ Both products are PN-based, but ingredient composition, concentration, and treatment areas may differ. Results and perceived discomfort vary depending on individual skin condition and injection technique.
Treatment Results Should Not Be Judged by Pain Differences Alone
Whether Lidocaine is included is mainly related to comfort during injection. Changes in skin texture and fine lines should be considered separately. The presence of Hyaluronic Acid also does not mean the product serves the same purpose as a volumizing filler. Desired skin changes and the intended purpose of each product should be evaluated together.

3. Four Skin Booster Treatment Options
Even when treatments are grouped under the term skin booster, the ingredients used and expected changes can vary. Rejuran uses PN, Ever Wrinkle is based on PLLA, Rejuvelook combines PN with Juvelook-based treatment, and Skin Botox uses Botulinum Toxin. The following four examples are not rankings, but illustrations of different treatment approaches.
Rejuran (Rejuran Healer / HB Plus)
Rejuran is a PN-based treatment used to support skin texture and fine lines. Rejuran Healer is a PN-centered formulation, while HB Plus includes added Hyaluronic Acid and Lidocaine. Although both belong to the Rejuran line, they differ in how hydration and injection-related discomfort are addressed, so the choice depends on skin condition.
Ever Wrinkle
Ever Wrinkle is a PLLA (Poly-L-Lactic Acid)-based skin booster designed to stimulate collagen formation within the skin. It focuses on gradual improvement in skin firmness and fine lines and works differently from Hyaluronic Acid-based treatments that directly supplement moisture. The timing of visible changes and skin response varies by individual.
Rejuvelook (Rejuran + Juvelook)
Rejuvelook refers to a combination approach that incorporates Rejuran PN with Juvelook-based PDLLA and Hyaluronic Acid. It combines PN-based skin texture care with collagen stimulation. This does not necessarily mean the products are mixed in a single syringe; the treatment sequence and areas are determined individually.
Skin Botox
Skin Botox involves distributing small amounts of diluted Botulinum Toxin into superficial skin layers. It is used to address sebum production, visible pores, and fine wrinkles, and its mechanism differs from skin boosters that inject PN or collagen-stimulating ingredients. The possibility of affecting facial expression muscles should also be considered.
“Even among skin boosters, each treatment plays a different role in the skin.”
— Compare Rejuran PN, Ever Wrinkle PLLA, the Rejuvelook combination approach, and the toxin-based mechanism of Skin Botox.
4. Is Rejuran HB Plus Less Painful Than Rejuran Healer? Understanding Treatment Discomfort
The sensation of the needle entering the skin and the pressure felt as the product is injected are different experiences. The Lidocaine in HB Plus is included to reduce discomfort, but the actual experience is influenced by injection depth, speed, treatment area, and individual sensitivity.
| Item | Key Features | Check Point |
|---|---|---|
| Anesthetic Ingredient | HB Plus contains Lidocaine, which is intended to reduce discomfort while the product is being injected. | Rejuran Healer does not contain Lidocaine. This is one of the key differences between the two formulations. |
| Needle and Injection Sensation | Even with an anesthetic ingredient, a stinging sensation from the needle and pressure during injection may still be felt. | Perceived discomfort can vary by area, such as the forehead, cheeks, and eye area, because nerve distribution and skin thickness differ. |
| Additional Pain Control | Additional pain-control methods such as numbing cream or cooling may be considered when needed. | Numbing cream does not eliminate all sensation, so individual sensitivity should still be taken into account. |
| Immediate Post-Treatment Reactions | Regardless of the product, temporary small raised bumps, redness, tenderness, bruising, or swelling may occur. | The time it takes for these marks to fade depends on skin condition and injection volume. If they persist for an extended period, they should be evaluated. |
※ Pain-related information describes general characteristics. Actual sensation may vary depending on anesthetic ingredients, injection technique, treatment area, and skin sensitivity.
Aftercare Is Still Important Even If the Treatment Feels Less Painful
Feeling less discomfort during injection does not mean swelling or raised bumps will not occur. Lidocaine is primarily included for pain control, while needle marks and temporary skin reactions should be monitored separately. Treatment discomfort should be evaluated by distinguishing sensations during the procedure from reactions afterward.
What to Check Before Rejuran HB Plus Treatment
- You have had an allergy or adverse reaction to Lidocaine or other local anesthetic ingredients
- You are pregnant, breastfeeding, or planning pregnancy
- There is a skin infection, inflammation, or open wound in the planned injection area
- You are taking medications, including those that may affect blood clotting
- You have experienced an allergy or severe swelling from fish-derived ingredients or previous injectable treatments
Ingredient allergies, existing medical conditions, current medications, and recent skin treatment history should be disclosed to the medical professional before treatment. Depending on skin condition, the timing may be adjusted or treatment may be postponed.

5. Rejuran HB Plus Aftercare and Precautions
Small injection marks that are not immediately noticeable may remain on the skin surface after treatment. Early aftercare should focus on minimizing friction and strong heat exposure while monitoring changes in swelling, pain, and redness.
| Item | Key Features | Check Point |
|---|---|---|
| Skin Irritation on the Day of Treatment | Do not repeatedly touch or rub the injection area firmly. | Avoid exfoliants and irritating skincare products until the skin has stabilized. |
| Cleansing and Makeup | Follow individualized instructions regarding when to resume cleansing and makeup based on the condition of the injection sites. | Keep makeup tools clean and do not forcefully cover or scratch small injection marks. |
| Raised Bumps, Swelling, and Bruising | Temporary small raised bumps at injection points, redness, tenderness, or bruising may occur. | If marks persist for a long time or swelling and pain gradually worsen, the condition should be evaluated. |
| Heat, Exercise, and Alcohol | During the early recovery period, you may be advised to avoid saunas, hot baths, strenuous exercise, and excessive alcohol consumption. | The timing for resuming these activities varies depending on skin response and treatment area, so follow the instructions you were given. |
※ The severity and duration of raised bumps, redness, bruising, and swelling may vary depending on skin condition, injection site, and treatment volume.
Worsening Heat Sensation or Allergic Reactions Require Prompt Evaluation
Mild redness or injection marks may occur temporarily. However, if pain and swelling worsen rapidly or severe heat sensation, pus, or fever develops, contact a medical professional immediately. Severe allergic reactions such as difficulty breathing, sudden swelling of the lips or face, or widespread hives require emergency medical attention.
6. Rejuran HB Plus FAQ: Frequently Asked Questions
Q1. Do Rejuran HB Plus and Rejuran Healer Have the Same Ingredients?
Both products are based on PN. However, HB Plus also contains Hyaluronic Acid and Lidocaine. Sharing one core ingredient does not mean that their full ingredient composition or treatment purpose is identical.
Q2. Is Rejuran HB Plus Less Painful Than Rejuran Healer?
HB Plus contains Lidocaine to help reduce discomfort. It may therefore reduce injection-related pain, but it does not eliminate the sensation of the needle entering the skin. Actual discomfort varies from person to person.
Q3. Is It the Same as a Volumizing Filler Because It Contains Hyaluronic Acid?
No. Even though both may contain Hyaluronic Acid, the formulation and intended use are different. HB Plus is designed with skin condition, fine lines, and hydration in mind and is not the same as a volumizing filler used to fill larger facial hollows.
Q4. How Long Do Raised Bumps or Swelling Last After Treatment?
Small raised bumps or redness may occur temporarily and usually subside over time. However, depending on injection volume, treatment area, and skin condition, they may last for several days or longer. If they persist or worsen, they should be evaluated.
Q5. How Many Rejuran HB Plus Treatments Are Needed?
There is no single number of sessions that applies to everyone. The interval and number of treatments should be determined based on current skin condition, treatment goals, and previous treatment response. One person’s experience cannot predict the outcome for everyone.
Q6. What Should Be Checked Before Rejuran HB Plus Treatment?
A history of Lidocaine allergy, reactions to fish-derived ingredients, and any active skin inflammation should be checked beforehand. If pain, heat sensation, or swelling worsens after treatment or systemic allergic symptoms appear, notify a medical professional immediately.
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Conclusion: Rejuran HB Plus and Rejuran Healer Differ in Ingredient Composition and How Injection Discomfort Is Addressed
Dry, rough skin may involve not only moisture loss but also uneven texture, fine lines, and changes in firmness. Rejuran HB Plus and Rejuran Healer both use PN as a core ingredient, but HB Plus also contains Hyaluronic Acid and Lidocaine. The most appropriate option can be considered based on dryness, desired treatment goals, and sensitivity to injection discomfort.
The presence of Lidocaine does not mean pain will disappear completely or that results will be uniformly different. Skin condition and the intended purpose of the product should be considered, and post-treatment reactions such as raised bumps, swelling, and redness should be monitored. If severe heat sensation or allergic symptoms occur, contact a medical professional without delay.
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Please Note.
#. Skin condition, injection site, pain sensitivity, and post-treatment reactions may vary by individual.
#. Product selection, injection site and volume, retreatment timing, and aftercare should be determined according to skin condition and previous treatment history.
